Integrated Immune Cell-Cell Communication Networks Underpinning Rheumatoid Arthritis Pathogenesis

Cell cycle implications in the pathogenesis of rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by hyperplasia of the synovial lining cells, angiogenesis, and infiltration of mononuclear cells resulting in pannus formation, cartilage erosion and ultimately joint destruction. Synovial tissue (ST) fibroblast hyperplasia is reminiscent of tumor-like proliferation and is a major cause of cartilage destruction in the RA ...

[The B cell in the pathogenesis of rheumatoid arthritis].

Classically, B-cells have been considered to play a secondary role in the pathogenesis of rheumatoid artritis, restricted to the production of auto-antibodies. Nevertheless, the unexpected good clinical response that the systemic depletion of B-cells has demonstrated in a well-controlled clinical trial in patients with rheumatoid artritis has revitalized the interest in this cell type in the pa...

Pathogenesis of Rheumatoid Arthritis

[Pathogenesis of rheumatoid arthritis].

Rheumatoid arthritis (RA) is an autoimmune systemic disease that primarily affects joints. Etiology and the pathogenesis of RA are complex, involving many types of cells, among others macrophages, T and B cells, fibro- blasts, chondrocytes and dendritic cells. Despite well documented role of many genes and epigenetic modifications in the development and evolution of the disease, in most RA pati...

The pathogenesis of rheumatoid arthritis.

From the College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom (I.B.M.); and the Department of Internal Medicine 3, University of Erlangen–Nuremberg, Erlangen, Germany (G.S.). Address reprint requests to Dr. McInnes at the College of Medical, Veterinary, and Life Sciences, University of Glasgow, Level 4, Sir Graeme Davis Bldg., 120 University Pl., Gla...